does acromegaly cause hypertension

Acromegaly can result in hypertension. This link primarily stems from the overproduction of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) in individuals with acromegaly, which can impact the cardiovascular system and raise blood pressure.

Firstly, the excessive secretion of GH can lead to the proliferation of cells in the heart and blood vessel walls, causing cardiac enlargement and vascular sclerosis, common contributors to hypertension. Secondly, an overabundance of GH may also decrease insulin sensitivity, leading to insulin resistance, which is associated not only with the development of diabetes but also with the onset of hypertension. Furthermore, acromegaly patients often suffer from sleep apnea syndrome, a condition characterized by recurrent episodes of breathing cessation during sleep, which can exacerbate hypertension risk by disrupting normal sleep patterns and increasing sympathetic nervous system activity.

Hence, it is essential to closely monitor and manage hypertension in individuals with acromegaly. Regular blood pressure checks are advised, along with appropriate treatment under a physician's guidance. Additionally, maintaining a healthy lifestyle, including a balanced diet, regular exercise, and avoiding smoking, can aid in controlling blood pressure and enhancing overall health.