hypertension and uric acid

There is a certain correlation between hypertension and uric acid levels. Typically, hyperuricemia may heighten the risk of developing hypertension, and individuals with hypertension often exhibit elevated uric acid levels.

Uric acid is the end product of purine metabolism. When there is a disruption in purine metabolism, either overproduction or underexcretion of uric acid can lead to increased levels in the bloodstream. Research indicates that hyperuricemia can cause endothelial dysfunction and promote arteriosclerosis, thereby raising the risk of hypertension. Moreover, uric acid can exacerbate cardiovascular damage through mechanisms such as triggering inflammatory responses and increasing oxidative stress.

Hypertension can also influence uric acid metabolism. Patients with hypertension may experience reduced uric acid excretion due to altered renal hemodynamics, leading to further elevation of uric acid levels. Additionally, certain antihypertensive medications, like diuretics, can impact uric acid excretion and contribute to higher uric acid levels.

For patients with both hypertension and hyperuricemia, it is important to follow a low-purine diet, limiting the consumption of high-purine foods such as animal organs and seafood. Maintaining a balanced diet, controlling body weight, abstaining from smoking, moderating alcohol intake, and engaging in regular physical activity can help lower uric acid levels. Under a physician's supervision, the judicious use of antihypertensive and urate-lowering medications, along with regular monitoring of blood pressure and uric acid levels, can help prevent complications.