l-citrulline hypertension

L-Citrulline, an amino acid, is metabolized in the body to L-arginine, which then generates nitric oxide (NO) via nitric oxide synthase. Nitric oxide acts as a key vasodilator, aiding in the relaxation of blood vessels, and may thus offer some adjunctive therapeutic benefits for individuals with high blood pressure. However, the efficacy of L-citrulline in reducing blood pressure can vary among individuals and may be influenced by factors such as genetic differences, dosage, and duration of supplementation.

Clinical trials often employ L-citrulline supplements to evaluate their effect on blood pressure. Some studies have indicated that moderate supplementation with L-citrulline may assist in lowering blood pressure in patients with mild to moderate hypertension. For instance, a study observed significant reductions in both systolic and diastolic blood pressure among participants who supplemented with 3 grams of L-citrulline daily for four weeks. Another investigation suggested that the combined use of L-citrulline and L-arginine might yield superior hypotensive outcomes.

While L-citrulline holds promise as a potential hypotensive agent, it should not be seen as a standalone treatment for hypertension. Individuals with high blood pressure should adhere to a comprehensive treatment regimen under medical supervision, encompassing pharmacological therapy, dietary modifications, and lifestyle adjustments. Moreover, the safety and efficacy of L-citrulline as a supplement require further validation through clinical research. Consequently, patients contemplating the use of L-citrulline as part of their treatment strategy are advised to seek counsel from healthcare professionals and to follow their recommendations.